In June 2022, the FDA granted talquetamab a breakthrough therapy designation.3. This is a target that is present on plasma cells and has come up as a newer target that can be exploited for disease control. HHS Vulnerability Disclosure, Help Injection-site reactions were observed in 7.9% of patients. But I'm curious then, maybe we can talk a little bit about the side effects. The immunotherapy being trialled is called talquetamab. Anemia, in this context, can be worrisome as a potential sign of emerging blood cancer. Xerostomia . Methods: At least he plans to, but we have zero CAR-T capacity and no idea when the situation . technology has been in development for decades, Rewired genetic 'clock' slows aging and increases cellular lifespan, Surfcycle: A highway-speed, lane-splitting stand-up scooter on steroids, Astronomers spot nearest star-destroying black hole. Talquetamab is an IgG4 Fc-containing BsAb targeting G- protein-coupled receptor family C group 5 member D . Copyright 2022 Massachusetts Medical Society. The primary end points - the frequency and type of dose-limiting toxic effects (study part 1 only), adverse events, and laboratory abnormalities - were assessed in order to select the recommended doses for a phase 2 study. The years biggest meeting on blood diseases kicked off this past weekend. As part of CancerNetworks Face-Off video series, Sikander Ailawadhi, MD, professor of medicine in the Division of Hematology/Oncology at the Mayo Clinic, Jacksonville, Florida, discussed results from the phase 1/2 MonumenTAL-1 trial (NCT04634552), designed to investigate talquetamab in heavily pretreated patients with relapsed/refractory multiple myeloma. For full disclosures of the study authors, visit ash.confex.com. This years meeting, hosted in New Orleans, put a spotlight on new kinds of antibody drugs for cancer, including some that home in on a novel target in multiple myeloma. CRS and cytopenia were primarily observed in early cycles and were reversable. But there are six trials recruiting! "It seems the total effect is a real drying effect. Apr 28, 2023 11:39am. Cancer Treatment Side Effects. Epub 2022 Dec 11. This activates an immune response to destroy myeloma cells by bringing T cells to the cancer, a strategy that researchers described as bringing your army to the enemy. It also uses a different target than other approved therapies; in this case, the target is a receptor expressed on the surface of cancer cells known as GPRC5D. A low blood cell count, called cytopenia, was among the most common adverse events . Subscribe to the BioPharma Dive free daily newsletter, Subscribe to BioPharma Dive for top news, trends & analysis, The free newsletter covering the top industry headlines, National Institutes of Allergy and Infectious Diseases. The authors concluded that the dose-escalation part of this first-in-human phase I/II study showed that subcutaneous epcoritamab had a manageable safety profile, with no grade 3 or higher CRS events, and induced robust single-agent antitumour activity in heavily pretreated patients. Healthy plasma cells produce antibodies to help people fight disease. One of the things that I think is very telling with efgartigimod is, no matter what subgroup we looked at, it showed a benefit over placebo, said Broome. Management of Relapsed-Refractory Multiple Myeloma in the Era of Advanced Therapies: Evidence-Based Recommendations for Routine Clinical Practice. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, A safer blood thinner? Last year at ASH, I studied andlearned more about anew bi-specific antibody drug called talquetamab. Talquetamab (JNJ-64407564) binds to GPRC5D and CD3 to induce T-cell . (Funded by bluebird bio and Celgene, a Bristol-Myers Squibb company . The safety data imply that no laboratory or cardiac monitoring is necessary with this drug. Of these, dysgeusia, dry mouth, and dysphagia were the most experienced symptoms. Bethesda, MD 20894, Web Policies Oral and dermatologic TEAEs, though generally mild, present an opportunity for oncology nurses to improve patient quality of life. Talquetamab induced a substantial response among patients with heavily pretreated relapsed or refractory multiple myeloma. So those are side effects of both bispecific antibodies and CAR-T cells. We're not used to seeing that, but something important to keep in mind. Talquetamab, also known as GPRC5D T cell-redirecting antibody, recruits T cells to tumor cells and activate T cells. Current treatment options for ITP, while [there] are many, can be associated with comorbidities, unsatisfactory efficacy and duration of effect, said Catherine Broome, a study author and associate professor of medicine at the Georgetown Lombardi Cancer Center in Washington, D.C., at an ASH press conference. One of these was the MonumenTAL-1 trial, which is a clinical trial for a newer bi-specific antibody called talquetamab, in patients with relapsed/refractory multiple myeloma. . 2023 Mar 18;15(6):1839. doi: 10.3390/cancers15061839. However, research has not proven these mushrooms can prevent cancer. Lindsay Diamond, MSN, AGNP-C, AOCNP, discusses findings from CheckMate 274 and other data presented during the 2023 ASCO Genitourinary Cancers Symposium. After an initial phase generated encouraging results in terms of safety and efficacy, researchers began enrolling additional patients to assess the agents efficacy with two different dosing regimens0.4 mg/kg weekly and 0.8 mg/kg every other week. Talquetamab binds to both T cells and multiple myeloma cells. Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. This is a list of most of the side effects I've had since I started talquetamab. Nurses Exchange Best Strategies in Improving Delivery of Hepatic Artery Infusion Pump Education. Looking forward to more breakthroughs. Hydrate, hydrate, hydrate, she said. Duration of response is good too. We've talked about this, but just to . Accessibility The Janssen Pharmaceutical Companies of Johnson & Johnson. N Engl J Med. The https:// ensures that you are connecting to the Epub 2022 Jun 5. 2023 Healthline Media UK Ltd, Brighton, UK. We see these [new drugs] as being part of regimens that will be used as complementary mechanisms of action, based upon sequencing, trying to address specific patient subgroups and disease characteristics., Chari, from Mount Sinai, agreed. Were looking at all of that, to try to figure out how to optimize the combination of these drugs in a highly effective regimen, said Tendler. It is scheduled to be annotated soon. Conclusions: As with the oral reactions, Aronson acknowledged that no therapeutic interventions have been identified as best practice in addressing dermatologic reactions. Kikuchi T, Tsukada N, Nomura M, Kasuya Y, Oda Y, Sato K, Takei T, Ogura M, Abe Y, Suzuki K, Ishida T. Ann Hematol. Ongoing trials are assessing the optimal phase 2 dose, as well as assessing the agents efficacy in combination with approved and investigational therapy. Phase trial confirmed a 70% response rate in patients with advanced disease. 2023 Apr 5;15(7):2160. doi: 10.3390/cancers15072160. sharing sensitive information, make sure youre on a federal Were hoping that this will soon become available so that patients can benefit.. Known in full as G protein-coupled receptor, family C, group 5, member D, the protein found on cancerous plasma cells drew attention over the weekend as Johnson & Johnson unveiled new data for an experimental multiple myeloma treatment. To explore the feasibility of talquetamab in the RRMM setting, a first-in-human phase I study of talquetamab in patients with RRMM was conceived (NCT03399799).The results were presented by Ajai Chari during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition 1 and are summarized below.. Study design 1. Bluebird got a much-needed lift this year when U.S. regulators approved two of its gene therapies. Type. Lindsay Diamond Discusses Ongoing Role of Immunotherapy in Bladder Cancer. (If you just need to know, that stands for G Protein-coupled Receptor class C Group 5 member D.). Retrieved from, JMJ Launches Free Toolbox Talks App to Make Safety Accessible to All, Azzur Group Hosts Groundbreaking for Devens, MA Cleanrooms on Demand Facility, Vial VP of Business Development, Daniel Gallagher, to Present at Precision in Clinical Trials , Vivera Secures United Kingdom Patent for Innovative ZICOH Smart Inhaler Device, By signing up to receive our newsletter, you agree to our. Talquetamab side effects. The cases occurred in one adult and one younger study participant. sneezing. The . Talquetamab had moderate side effects. 2023 Apr 28. doi: 10.1007/s00277-023-05218-1. Talquetamab. We have lot of patients start a nail hardener at the onset of therapy.. Immune checkpoints are a potential target for MM therapy since they are overexpressed in MM plasma cells . It is graphic, but it prepared patients for what to expect.. We've had, for example, a drug with ocular or eye toxicity. The gist was that the temporary side effect was nothing if the drug works! My husband and I live in Spokane Washington but spend our winters in Lake Havasu City Arizona. At the time of data cut-off, 76 patients had been enrolled in the trial at Mount Sinai Hospital. Patients would describe this as everything tasting like cardboard or sawdust, or that things that they used to enjoy now tasted completely different.. In a separate cohort, 51 patients who had previously received therapies that redirect T cells showed a response to talquetamab. . The researchers said very few patients (5-6%) stopped talquetamab treatment because of side effects. Ive been fighting Multiple Myeloma for more than 15 years. Talquetamab (JNJ-64407564) is an investigational bispecific antibody. Get the free daily newsletter read by industry experts. Ajai Chari, MD, discusses the safety and efficacy of talquetamab plus daratumumab in heavily pretreated patients with multiple myeloma, initial data from phase 1b TRIMM-2 trial, and the potential . Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Other than some minor fatigue and some of the normal side effects of being 66, Im feeling great! Oral antihistamines and topical corticosteroids are useful in addressing a body rash and injection-site reactions. But it is important to keep in mind that some of the side effects were a bit unique. Talquetamab is a bispecific antibody, a type of monoclonal antibody that redirects T cells to act against myeloma cells. ABSTRACT 291: Phase I/II, first-in-human study of REGN5458 in 45 patients with relapsed and/or refractory multiple myeloma . Diagnosis and Management of Adult Malignancy-Associated Hemophagocytic Lymphohistiocytosis. Topics covered: Drug commercialization, pharma salesforces, generic and biosimilar competition, drug advertising and much more. Here are three storylines to emerge so far. (Funded by Janssen Research and Development; MonumenTAL-1 ClinicalTrials.gov number, NCT03399799.). His interests focus on psychedelic science, new media, and science oddities. Cure Hub Side Effect Solutions My Journal University Coach Connect . Janssen is responsible for the development and commercialization of talquetamab. Drilling down into the data, there were 59% very good partial responses (VGPR) with the lower dose, along with . Before New blood cancer therapy successful in three-quarters of trial patients, The new treatment is currently under application for review by the FDA. Just under three-quarters of participants given a lower or higher dose of talquetamab in the Phase 2 portion of J&Js study responded to treatment, with around a third of each group achieving remission of their cancer. Subscribe to the weekly "HealthTree Community for Myeloma Newsletter" for Myeloma news, life 5. scaling of the skin. I am looking forward to seeing how the reduction in frequency of administration will improve the side effects I've been experiencing. Living With Cancer. The response rate observed in the study, which Dr. Chari explained is higher than . A total of 5 patients experienced dose interruptions because of a TEAE. . Many myeloma treatments (CAR-T, BLENREP, other bi-specifics, etc) target BCMA, an antigen found on 80-100% of myeloma cells. The results suggest that talquetamab could give hope to patients with refractory myeloma. There are currently three FDA-approved bispecfiic antibody therapies on the market (primarily targeting cancers), and more than 100 prospective antibodies in clinical trials (aimed at everything from Alzheimer's to diabetes). (Its also found on hairfollicle cells but dont worry youre not going to lose your hair again.) Both of those therapies bind to BCMA, a protein targeted by a wave of new drugs from Roche, Regeneron, AbbVie and Pfizer. Almost all patients had grade 3 or 4 toxic effects, most commonly hematologic toxic effects and cytokine release syndrome. Background: Ive been on pretty much every approved drug regimen and theyve all worked really well for me. Oncology nursing always has their finger on the pulse of the patients psychosocial [needs]. (a median of six previous lines of therapy) or who could not receive these therapies without unacceptable side effects. The primary end points - the frequency and type of dose-limiting toxic effects (study part 1 only), adverse events, and laboratory abnormalities - were assessed in order to select the recommended doses for a phase 2 study. It lasted about a year. New data from an ongoing Phase 1/2 clinical trial has revealed an experimental immunotherapy led to successful response rates in 73% of patients suffering from multiple myeloma, a deadly form of blood cancer. Whats really great is that some myeloma cells NOT having BCMA MIGHT have GPRC5D. Topics covered: startup launches, funding, IPOs and much more. Dr. Ajai Chari, director of clinical research in the Multiple Myeloma Program at The Tisch Cancer Institute and lead author of both studies, explained for Medical News Today how it works: Basically one side is binding to the immune cells known as T cells, and the other side is binding to the myeloma cancer cell, and when those T cells are brought into proximity of the cancer [] they release chemicals that poke holes in the cancer cell membrane and the cancer cells die., Dr. Baker was cautiously optimistic about the therapy: Talquetamab sticks to both cancer-killing immune cells and myeloma cells, helping the immune system to recognize and destroy the cancer.
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talquetamab side effects